Joel Smith, Florida State University

Redox Economic Alkaloid Synthesis

Abstract: Biologically active alkaloids continue to serve as a means of biomedical discovery in addition to serving as forcing functions for the invention of new chemical transformations. Thus, the concise redox-economic construction of these molecular targets in the context of multi-step synthesis has remained a prevailing research focus in our lab. Our lab’s recent synthetic efforts related to alkaloids from the ergoline and manzamine families of alkaloids will be discussed, articulating the breadth of targets that can be accessed by this strategic approach. In addition, both fundamental and translational opportunities afforded by our work in this area will be highlighted.