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From the Lab to the Bush and Back: A case for Ecological Genomics of Aging

The decline in whole-organism performance with age (or aging), is a near-universal feature of species in the tree of life, and a major constraint on fitness and longevity. Interestingly, there is a large variation within and among species in the pace of aging both under the same and under different environmental conditions. A literature trove accounting for molecular and physiological causes and correlates of aging in captive organisms (e.g., worm, fruit fly, and mouse) exists. We understand much less about critical sources of selection and the loci targeted by selection for differential responses in wild or free-living natural populations. Our primary goal is to address this gap by answering the following questions: 1) Which environmental components are critical in cuing for different rates of aging within and among natural populations? 2) What is the source of intrinsic variation recruited to respond to these selective cues? 3) Is the mechanism of differential rate of aging conserved across wild populations and/or species, and between wild and laboratory populations? We will approach these questions by integrating a suite of traditional genetics and modern omics methods, over scales of biological organization (from genes to phenotype), across populations and species, and between contrasting natural conditions. The answers to these questions will generate novel hypotheses and testable predictions with potential applications for both gerontological research and species conservation. 
https://biology.missouri.edu/people/ngoma

Accommodations for disabilities may be made by contacting 541-737-2993 or ib@oregonstate.edu

  • Waad Al Harbi
  • Amanda Galbreath

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Webinar ID: 984 9985 9340

Passcode: 742060

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International numbers available: https://oregonstate.zoom.us/u/aezNhJlbGo

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