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PhD Preliminary Oral Exam – Bo Wu

Printed nanocomposite-based sensors for sensitive label-free electrochemical detection of biomarkers

Electrochemical biosensors are promising analytical tools widely used in medical diagnostics and environmental monitoring, as they are cost-effective, easy to miniaturize and can be designed to provide sensitive and selective recognition of target analytes. The sensitivity and selectivity of the electrochemical biosensor are governed by the efficiency of signal transduction and the choice of biological receptors. Traditional electrochemical sensors utilize glassy carbon electrodes or screen-printed carbon electrodes in company with redox reagents as an electrochemical transducer that have limited electron transfer efficiency and increased complexity. Also, most of these biosensors rely on biological receptors for biorecognition, such as antibodies, enzymes, and nucleic acids, that are lock of chemical/physical stability. In this work, we presented a novel electrochemical biosensor without the need of redox couples in analytes to demonstrate sensitive detection of several analytes, including hydrogen peroxide, glucose and steroid hormones. The sensor incorporates a redox-active layer on the screen-printed electrode to enhance signal transduction and utilizes target-selective molecularly imprinted polymer (MIP) to provide a robust approach for the recognition of target molecules. The new device enables quantitative measurement of cortisol levels in a clinically relevant concentration range.

Major Advisor: Li-Jing Cheng
Committee: Chih-hung Chang
Committee: John Labram
Committee: Matthew Johnston
GCR: Oksana Ostroverkhova

Thursday, March 5 at 2:00pm to 4:00pm

Weniger Hall, 285
103 SW Memorial Place, Corvallis, OR 97331

Event Type

Lecture or Presentation

Event Topic

Research

Organization
Electrical Engineering and Computer Science
Contact Name

Calvin Hughes

Contact Email

calvin.hughes@oregonstate.edu

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